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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'e8712312bc7cdbd46ca8998183202fb496ec54f121d9c2c7e05489f8eb86f347' 
  AND token = 'd2vj+mell/VftnanfzS+KE6rnhNup/tBESUuJinLj10=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}