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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '903d78a36516d741050e26260bda2f158b6f9de636719a3e7e6b7db2b315d6a8' 
  AND token = 'JV58QRK4BjTVE6KpO3X5/5J60hJvi4UE2gppbQf4tFg=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}