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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '81da0db32461f7bd02f70bedfc277eb969100e4e0ff93360063bd34110bb8b52' 
  AND token = 'O8o0DTukkrgji1b8nRNVyBVb85Y6tZi5cES19ZhtVrg=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}