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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '888879811a8ede6b5fd7ea894083d656a7771d4c5659ae6bf803fcce5e4cd393' 
  AND token = 'FKhFNcZK/yB3HDAHz9GM+HTH7MFAaX3IpJM4OPHO6E4=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00017

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}