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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '2a20e7a4c027db4482216fa708033f443f65bb6c8ad110f6736df484af39e786' 
  AND token = 'Le2Wl+Dc6YH7md9tYFtikVTn1fibz2YnX28oS0ZotLw=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}