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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '41d927932dbd5a0d7932dfe99f81462f90ba022c807a08d9585be4d7c9ad9f08' 
  AND token = 'qI0Wk/o1x8sj+wUr/jubPDdr3VVlZbNwJARXfDAB3Us=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}