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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'b2f4127b3afb63d1b37a59a1627550891148ffaa84c9244974a2a44749b9e190' 
  AND token = 'Iu/7pUMOcJT6mC1QzLDjrhV7GQxr/z7E1WhjWpMFb4M=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}