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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '2c8486204fcea14f3a734b464be71603bc6d8378f7f6a100fd5100e3b00eaa70' 
  AND token = '86KMNAc/NE7wqEjdbCOaJP2AvMIbn/V5K1zqU60xVig=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}