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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'a8125dfe05f5b02d0137417b3290279a44a2a97e8fbd28fe01d63e15367a2a1b' 
  AND token = 'MNByHcBYuNiBhdiiAvJAoya+hGwAG4f2cjFBn/gjaZ0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}