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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '539553567343b77824482685e8fbdde69e6e8b10e8d63f340af322159335d082' 
  AND token = 't1JqXH1p+NFYcvqP42aB2lk8fqRkiZytIXXqNdGXBiA=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00015

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}