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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '46155528065727af49ead9b49aa987fa2631f26ecaddea16e357d45fa27b6c29' 
  AND token = 'uR+lKJTi8CCxk553A5Np3cQxEzZ4Cc0YKEaeLOEyi9U=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}