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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '2d374e5926a1c2ee71b721ce92754396262a1f3e416866bdbe681f3bcccf78dd' 
  AND token = 'GJZ2SqY6nArn8OiX+hDUOgrMKOag1qNU95zxdQw9RMM=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}