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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '53a0f166594251e8a920995d5eadc5d117bc02d296290aa05c1b3a00b3d4d5a4' 
  AND token = 'rScWm/4SQ0Ks33pdN6cXU072HIa8uRDWhysplAgpDPg=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}