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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '485cd80ef697bda2727405e3195f3c0ffacbcb3faa4fd17dc9dddd88ea267195' 
  AND token = '1P62WIonvFF+/o5dCXzUfMd4enOz+4OQ+Hb6xoTH5H8=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}