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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '4a52bb72292a409001360b23b6a41c831f2ba42fe3c3800a42b4f65122391a95' 
  AND token = '+vVfnOxZ5HvN7rdUwnAs7M5rZOUCcCHqoLrTGIPs8cc=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}