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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '2a8123333eab6290a4bf9f46b7b69d9941dcf959f5c6412bb4459fb286cddff6' 
  AND token = '6Hp3WbFm0tf/JMnT2wjmR3Ahx4w8V+Wke0WTZfPyZVQ=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}