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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '81c41b2a9db5dd27f87055eb24722335db99a85ff82310305f026f5e232ce370' 
  AND token = 'nW2tMVMfJW0JhAP0AcmQ/lP2DlTYqnipzUqm0Y8v+Cg=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00017

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}