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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '48f1a94b8d4717a8d74fd4d23704edc022bc5050ee857ef2d54f5f910c537da8' 
  AND token = 'eHwZ4S+6y2AcwA5x1c3RCWGZIRu+qAsCNB3OMhZijPM=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}