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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'a3acd43e59a50a4ab130c1aebb030cf701fe4f7e01c37dfd85c859f17e940537' 
  AND token = 'NsRD592NYsMOSyJ//wjyiDLyJr+1kaBipztoKE40a44=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00015

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}