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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '21beb140a335243017d5e26b6889449e3a6e13771bd3baffacbc625ff220a5c7' 
  AND token = 'wNMY4cybBtQlG3cCR9CndEmoIWMWB2EVDrKgyIlkVDg=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}