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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '78c4c3fa42bcd1da947edaec03be8759b7f1c14a6719737f6f09d54ff0d12995' 
  AND token = 'eASzJD+QR92C2DWwSIRS+62k8SoaaeMwnkJp1ncsaEI=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00019

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}