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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'c0595f5a60e8f56c0bdd2649006b899ebf07f4105a2f10d4de861c402b77f01f' 
  AND token = 'PUzpvs+KCVKpKfx+bjG8JXwy12PpWNVl6c+Nsp6E3FE=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}