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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '9c4fa555bcd0fe72869b7a8ad7093c4e4cb4306a9733d6f8fba4f2d05126154a' 
  AND token = 'O6dOmLJev5wcLKxfE4QGJm5VSWL0+iLRDVkh2o0Y6SE=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}