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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'd2141c94f12ff7176c748118100380e84405108cab41f059a4f2f42ffa8c3286' 
  AND token = '0R148UG8X1nwNY0+v0d825dqeffukv4PrqfVgTWO23Y=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00016

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}