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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '597de43524c6b4ac2e1f0f31dbab9dff9be13e778057b6e4016f1d30298fef31' 
  AND token = 'dHuBpM+s/weGmb1WQnDR+DciX9ZUk+yWQbrrj0jP5Ts=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00019

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}