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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '42f0a16868d5fdf3696f165e4d63a4c354ea1665f0d8de65fb075dff2bb8b8dd' 
  AND token = 'CuM+7cp6RxKJ9efSA5oV3gWaV6zLU4J0FbQlzCFNOAg=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}