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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '397d5aa3ce748208e22b4b07f166b4d5844a6e426b78dc1130378693d548da16' 
  AND token = '6XL/3cu9Xwe3uWtou/tE1OhdxFsf4cRPe1F8HdRZPxQ=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}