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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '80681dc288a0be5395c51a85b41bbc4b78bcf9a9f58d263349f3a44f6922c1be' 
  AND token = 'bJsiQ8nUFNSKMSvXgp7C0mwuA1M5aT4msfXs5AyxxPE=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00017

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}