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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'e66206ca1321c9a8303c1c6af822ec462412cf39e02dbf2a059ad16381d4f9f4' 
  AND token = 'c+JN8WLqz3p/W1KftZzx7fKktBN0QDdsnOLCHBVbzXg=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00019

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}