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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '541a81bd73e324c7272f5c5ef8b9b72161c64471c51d5710fd73e5690296aa0a' 
  AND token = 'V//2hynEc8gB/zYTsn7qygoS+aoVPurACccXF/MetQY=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}