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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '46382a9f16bd1f360bd965e2e9019e886f024c823d8217f5fe195c75de2d7575' 
  AND token = 'Deu/3Ile4XUzsHLO+2ATPA5mi+XX40GSR7XOFLSzX4I=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}