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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '721631e54592df2fbb79f88a750d6193d2ae06daca0c3b3b57b8e1a60e4bec14' 
  AND token = 'l253PymDRqNpwXK2wx6YC3zTU9Pn7RMu1GCWXzY9Pjc=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00022

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}