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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '5d156b00d6239f3efd6a0f6ebce1845c5a03a8185e5e780e2a7e54f69b8a867f' 
  AND token = 'aKFThN47DeRMXA/Dp1cpti5nctV20gS3e0WjKAgOWzA=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}