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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '1225dafc321954a8970246c7a59e2e5401691fc2e52e7f5199381bb631224426' 
  AND token = 'lgoZ0Qj1TLzs7U1d9X1LJ1OdbGwuBWKeh94UHv9OUPk=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00022

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}