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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '2121c90df821ab7de37dcd4ea9ab22052ee6522d0e8b5e79afde50076583f30c' 
  AND token = 'f3WO4eZPvkvC3oBsEcToC/XY/y7x4yPG2je09jpMCm8=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00016

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}