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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'cb646d2391429faef32c3408245bbf45c329e1d363203dc32a8ed4c95db23010' 
  AND token = 'UUP0o7q2KErtzmgFenzDavUzaQnH1TtNXbpei3Ya3Ms=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00029

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}