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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '754c61230790c96f33c63d412aef6ee1e4f56880480190329c39db8ddcf1e60b' 
  AND token = 'JVcP4tgknX6CCkIyGy3s3EB6OLr++9A1jPyPiG6m7hM=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}