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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '750f442017949eadc5cb607d9a3601b4ac1aeeeb6c5251ba0e92857c00dfcc08' 
  AND token = 'W8ItgRI7L1W4HAwQQ8L0PeFbDd5iMsKm89zhMeevVQ0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00017

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}