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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '7e5fb7673fb6b0a21187ed75f162f8dac5f25546a134b1ece31754722977a6a9' 
  AND token = 'AL6P8FE+8lpxR2wt264/UFK5YZn4EcS6s5z6y/5lKQ0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}