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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '43023e576dfc05b2ee361e26e899402aa3a146b8044baee34047c0b49f1f7fad' 
  AND token = 'iOa+ApIu4FM2kgMPH/F/W789MNftp/xti5vw8CXfbmw=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}