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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '4400df691d0894319e9aab506a25c0281ef7f3a5e239ec4e456358e004a60326' 
  AND token = '0DBI+juyD2hn64c/uJPhmJC7GaAC1x5Rc8DxKX4Ig10=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}