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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'af3e5cc74bbb2ca363e065eb9fed5ba227506731c3cc65274c9dbc40c0a444c2' 
  AND token = 'xz8b+ooQ/kgYEjgeuikoUp0ziptqV6kHSVdm0LUb2Tg=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}