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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '201779f741c10a1205853ad242a4eb8c6743c2fe12792c8adeb2741b86c21dcd' 
  AND token = 'EBwGxLQmfmzM7PX0SrPZhAk74pyfuaDNkexiYAUd9tQ=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00017

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}