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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '5600bb535fd110a5fa4e0834fbad5874d59e0174b1c239e4330f7d3061d3b426' 
  AND token = '+p/Qp0R5P/p5Zv7bIMTNxFeY/b4dVLobH0/WJOhNGZ8=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}