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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '53143d8ea0ead36f1de95a3c86099d220aa19d4c47e25f1599815dacc023e147' 
  AND token = 'AyKPW0EWn4xP+MYqhxlCYPprGntotVJ9nTdMj+dlqI4=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00016

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}