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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '49db16a71a0d7ed48d915dc8b1afc4e4b473ac3ee257d9836f9b5c5b32ed24ff' 
  AND token = '4uoti7UJebfZb1eAatki6i28MfdvRsuCTZjD6nEFXCo=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00028

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}