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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'efe21e931c1583b6928c013f3bad8650190d8af89bce4d2d41cf26baf9c10d80' 
  AND token = 'UpXN03nKHDdYnGNTNXTegYnc44JZOVN7L2BeFESh158=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}