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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'b4d9817fdd104c532cf20f1732e70c07bf7981076dfdd973fd0300f6e1684c43' 
  AND token = 'p8qU7K1L1PpRB2hH+Rgn5gZvawDWkWRlP1CCS7XDX0M=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}