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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '6a72ecdf0e02d504fb4c0dc9d14a10d287b81307bce8c1b1da37978a1aade15b' 
  AND token = 'EPsH1GxUwA/6eVRNDkJPr4GsYgESqJUhZc/BI6bSbIQ=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00017

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}