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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '26a0252718d6a1e2a4913f8e8ceda226c34029a88cf961eab81b08fada3f1ac6' 
  AND token = 'iVXFhQ0xS+nZr7Aik41mHOmuLhsz3vxWYjHVTuwxuCQ=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}